Haiyun Song, Ph.D., Professor, Ph.D. Supervisor
School of Public Health
Shanghai Jiao Tong University School of Medicine
Email：songhaiyun@shsmu.edu.cn
//www.fsljb.com/sph/info/1075/1814.htm
Dr. Song has been focusing on the study of the mechanisms and applications of cancer or metabolic disease associated signaling pathways for many years. He was recruited as a subject leader by school of public health, Shanghai Jiao Tong University School of Medicine in 2017. In recent years, he is interested in the dysregulation of signaling pathways induced by exterior factors, such as risk factors from food and environment, and internal factors, such as abnormal gene functions, and their implications in the imbalance of nutrition and health as well as the onset and progression of cancer or diabetes. In these studies, he aims to reveal the underlying mechanisms through which nanomaterials or intracellular regulators manipulate the key signaling pathways essential for the maintenance of tissue homeostasis and stem cell microenvironment. These work will help to form strategies or find targets for personalized prevention and precise interference of critical illness such as cancers, metabolic diseases and neurodegenerations. He received the “one hundred talent” grant with priority support from the CAS and the “excellent youth” grant from the NSFC. As the corresponding author, he has published 22 papers that are indexed by SCI in recent years, with an average impactor factor of 8.5.
Recent publications：(*: corresponding author; IF: impact factor)
1. Liu C#, Hu X#, Li X#, Zhou Y, Wang H, Fan C*,Song H*.Reprogramming of Cancer Invasiveness and Macrophage Education via a Nanostructured Antagonist of the TGFß Receptor.Mater Horiz.2019 Oct 1; 6(8):1675-1681.（IF=14.4）
2. Li P, Ma Z, Yu Y, Hu X, Zhou Y,Song H*. FER promotes cell migration via regulating JNK activity.Cell Prolif.2019Sep; 52(5):e12656.（IF=5.0）
3. Ma Z, Li P, Hu X,Song H*.Polarity Protein Canoe Mediates Overproliferation via Modulation of JNK, Ras-MAPK and Hippo Signaling.Cell Prolif.2019 Jan; 52(1):e12529.（IF=5.0）
4. Yu Y, Liu L, Li X, Hu X,Song H*. The histone H4K20 methyltransferase PR-Set7 fine-tunes the transcriptional activation of Wingless signaling in Drosophila.J Genet Genomics.2019 Jan 20; 46(1):57-59.（IF=4.7）
5. Li X#, Xie X#, Ma Z#, Li Q, Liu L, Hu X, Liu C, Li B, Wang H, Chen N*, Fan C*,Song H*.Programming Niche Accessibility and In Vitro Stemness with Intercellular DNA Reactions.Adv Mater.2018 Nov 15; 30(46):e1804861.（IF=25.8）
6. Chen N#, Han Y#, Luo Y#, Zhou Y, Hu X, Yu Y, Xie X, Yin M, Sun J, Zhong W, Zhao Y,Song H*, Fan C*.Nanodiamonds-based non-canonical autophagy inhibitor synergistically induces cell death in oxygen-deprived tumors.Mater Horiz.2018 Nov 1; 5(6):1204-1210.（IF=14.4）
7. Li P#, Huang P#, Li X#, Ma Z, Wang H,Song H*.Tankyrase Mediates K63-Linked Ubiquitination of JNK to Confer Stress Tolerance and Influence Lifespan inDrosophila.Cell Rep.2018 Oct 9; 25(2):437-448.（IF=8.1）
8. Li X#, Song L#, Hu X, Liu C, Shi J, Wang H*, Zhan L*,Song H*. Inhibition of Epithelial-Mesenchymal Transition and Tissue Regeneration by Waterborne Titanium Dioxide Nanoparticles.ACS Appl Mater Interfaces.2018 Jan 31; 10(4):3449-3458.（IF=8.5）
9. Liu C, Li P, Chen N, Jiang Y, Shi J, Fan C,Song H*. Titanium Dioxide Nanoparticles Trigger Non-Canonical Receptor Endocytosis to Inhibit Wnt Signaling.J Biomed Nanotechnol.2017 Nov; 13(11):1522–1532.（IF=5.1）
10. Hu X#, Li X#, Yin M, Li P, Huang P, Wang L, Jiang Y, Wang H, Chen N*, Fan C*,Song H*. Nanodiamonds Mediate Oral Delivery of Proteins for Stem Cell Activation and Intestinal Remodeling in Drosophila.ACS Appl Mater Interfaces.2017 Jun 7; 9(22):18575-18583.（IF=8.5）
11. Yi H#, Wang Z#, Li X#, Yin M, Wang L, Aldalbahi A, El-Sayed N, Wang H, Chen N*, Fan C*,Song H*. Silica nanoparticles target a Wnt signal transducer for degradation and impair embryonic development in Zebrafish.Theranostics.2016 July 18; 6(11):1810-1820.（IF=8.8）
12. Yi H#, Li X#, Wang Z, Yin M, Wang L, Aldalbahi A, El-Sayed N, Wang H, Chen N, Chen L*, Fan C*,Song H*.Nanodiamonds interfere with Wnt-regulated cell migration and adipocyte differentiation in cells and embryonic developmentin vivo.Part Part Syst Char.2017 Jan; 34(1):1600208.（IF=4.5）
13. Huang D, Li X, Sun L, Huang P, Ying H, Wang H, Wu J*,Song H*. Regulation of Hippo signaling by p38 signaling.J Mol Cell Biol.2016 Aug 8; 8(4):328-37.（IF=6.9）
14. Li G#, Liu L#, Li P, Chen L*,Song H*, Zhang Y*.Gene expression profiling of selenophosphate synthetase 2 knockdown in Drosophila melanogaster.Metallomics.2016 Mar 16; 8(3):354-65.（IF=4.0）
15. Zhang Y#, Wang Z#, Li X, Wang L, Yin M, Wang L, Chen N*, Fan C*,Song H*.Dietary iron oxide nanoparticles delay aging and ameliorate neurodegeneration inDrosophila.Adv Mater.2016 Feb 17; 28(7):1387-93.（IF=25.8）
16. Chen N, Wang H, Huang Q, Li J, Yan J, He D, Fan C*,Song H*. Long-Term Effects of Nanoparticles on Nutrition and Metabolism.Small.2014; 10(18):3603-11.（IF=10.8）
17. Yin D#, Huang P#, Wu J,Song H. Drosophila protein phosphatase V regulates lipid homeostasis via the AMPK pathway.J Mol Cell Biol.2013 Dec; 6(1):100-2.（IF=6.9）
18. Zhong W, Lü M, Liu L, Sun J, Zhong Z, Zhao Y*,Song H*. Autophagy as new emerging cellular effect of nanomaterials.Sci Bull. 2013 Nov 25; 58(33):4031-8.（IF=6.3）
19. Schertel C#, Huang D#, Björklund M, Bischof J, Yin D, Li R, Wu Y, Zeng R, Wu J, Taipale J,Song H*, Basler K*. Systematic Screening of a Drosophila ORF Library In Vivo Uncovers Wnt/Wg Pathway Components.Dev Cell.2013 Apr 29; 25(2):207-19.（IF=10.4）
20. Wen Y, Xu Y, Mao X, Wei Y,Song H*, Chen N, Huang Q, Fan C, Li D*. DNAzyme-Based Rolling-Circle Amplification DNA Machine for Ultrasensitive Analysis of MicroRNA in Drosophila Larva.Anal Chem.2012 Sep 4; 84(18):7664-9.（IF=6.4）
21. Wang B, Chen N, Wei Y, Li J, Sun L, Wu J, Huang Q, Liu C, Fan C*,Song H*. Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila.Sci Rep.2012; 2:563.（IF=4.0）
