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修乐山

作者:   发布时间 :2021年09月01日

姓名:修乐山  职称:助理研究员

上海市浦江人才


联系方式:

办公室地址:上海市黄浦区重庆南路280号上海交通大学医学院西区老红楼412

办公室电话:021-63846590

邮箱:xiuls@sjtu.edu.cn

 

教育经历(从本科开始)

2011年09月至2015年06月,华北理工大学,本科

2015年09月至2018年06月,清华大学-北京协和医学院,硕士

2018年09月至2021年06月,清华大学-北京协和医学院,博士

2019年09月至2020年09月,美国杜克大学,联合培养博士

 

工作经历

2021年07月至今, 上海交通大学医学院,教师

 

社会/学术任职和活动

中国麻风防治协会皮肤性病与诊断分会委员

iMeta期刊青年编委

Infectious Medicine期刊青年编委

LabMed Discovery期刊青年编委

Scientific Reports期刊编委

Frontiers in Cellular and Infection Microbiology杂志客座编辑

 

科研方向/主要研究内容

新发突发传染病应急防控与病原体发现;One Health理念在传染病和耐药研究中的应用;细菌耐药机制与抗菌策略研发;病原体鉴定和耐药性检测技术研发与应用推广

 

科研项目

项目编号

项目类型

项目名称

起止年月

备注

23-526

美国中华医学基金

Exploiting environmental surveillance to track antimicrobial resistance and prevent healthcare-acquired infections

2024.1-2026.12

项目负责人

2022PJD035

上海市浦江人才计划

基于多系统多技术的淋球菌耐药性新型检测方法的研究

2022.10-2024.09

项目负责人

SJTU-UCL202401

UCL-SJTU Global Health Funding

Advancing Antimicrobial Resistance Surveillance in Hospital Environments

2024.01-2025.12

项目负责人


 

发表论文

  1. Xiu L*, Zhang L, Peng J*. Surge in Ceftriaxone-Resistant Neisseria gonorrhoeae FC428-Like Strains, Asia-Pacific Region, 2015-2022. Emerg Infect Dis. 2024, 30(8):1683-1686.

  2. Xiu L and Peng J*. Challenges and Considerations in Implementing Doxycycline Post-Exposure Prophylaxis for Sexually Transmitted Infection Prevention in China. Clin Infect Dis. 2024, 3:ciae309.

  3. Xiu L* and Yin K. Wastewater surveillance to track influenza viruses. Bull World Health Organ. 2024, 102(9): 623–623A.

  4. Xiu L*, Kassegne K, Yin J. Editorial: One Health in clinical microbiology. Front Cell Infect Microbiol. 2024,14:1404276.

  5. Xiu L*, Li H, Hu Q, Zhang Y, Chen SB, Wang C, Zhou XN, Chen JH, Yin K. A versatile microfluidic platform for malaria infection screening and Plasmodium species genotyping. EBioMedicine. 2023, 98:104898.

  6. Xiu L*, Liu H, Xie Y, Hu Q, Li H, Chen F, Wang C, Zhang Y, Hou L, Yin K*. Alternations of antibiotic resistance genes and microbial community dynamics on shared bicycles before and after pandemic lockdown. Sci Total Environ. 2023, 913:169625.

  7. Xie Y, Li H, Chen F, Udayakumar S, Arora K, Chen H, Lan Y, Hu Q, Zhou X, Guo X, Xiu L*, Yin K. Clustered Regularly Interspaced short palindromic repeats-Based Microfluidic System in Infectious Diseases Diagnosis: Current Status, Challenges, and Perspectives. Adv Sci (Weinh). 2022, 9(34):e2204172.

  8. Xiu L, Wang L, Li Y, Hu L, Huang J, Yong G, Wang Y, Cao W, Dong Y, Gu W*, Peng J*. Multicentre Clinical Evaluation of a Molecular Diagnostic Assay to Identify Neisseria gonorrhoeae Infection and Detect Antimicrobial Resistance. Int J Antimicrob Agents. 2023, 61(5):106785.

  9. Xiu L, Li Y, Zhang C, Li Y, Zeng Y, Wang F, Peng J. A molecular screening assay to identify Chlamydia trachomatis and distinguish new variants from wild-type. Microb Biotechnol. 2021, 14:668-676

  10. Xiu L, Binder RA, Alarja NA, Kochek K, Coleman KK, Than ST, Bailey ES, Bui VN, Toh T, Erdman DD, Grey GC. A RT-PCR assay for the detection of coronaviruses from four genera. J Clin Virol. 2020,128:104391.

  11. Xiu L, Li Y, Wang F, Zhang C, Li Y, Zeng Y, Yin Y, Peng J. Multiplex High-Resolution Melting Assay for Simultaneous Identification of Molecular Markers Associated with Extended-Spectrum Cephalosporins and Azithromycin Resistance in Neisseria gonorrhoeae. J Mol Diagn. 2020, 22(11):1344-1355.

  12. Xiu L, Yuan Q, Li Y, Zhang C, Tang L, Peng J. Emergence of ceftriaxone-resistant Neisseria gonorrhoeae strains harbouring a novel mosaic penA gene in China. J Antimicrob Chemother. 2020, 75(4):907-910.

  13. Xiu L, Zhang C, Li Y, Wang F, Peng J. High-resolution melting analysis for rapid detection of the internationally spreading ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone. J Antimicrob Chemother. 2020, 75(1):106-109.

  14. Xiu L, Zhang C, Wu Z, Peng J. Establishment and Application of a Universal Coronavirus Screening Method using MALDI-TOF mass spectrometry. Front Microbiol. 2017, 8:1510

  15. Wang C, Xiu L*, Hu Q, Zhong R, Guo X, Peng J, Yin K. CRISPR-based platform for clinical diagnosis of Neisseria gonorrhoeae and simultaneous tracking of ceftriaxone-resistant FC428 clone. Chem Eng J. 2024

  16. Li Y#, Xiu L#, Wang L, Zhang L, Wang F, Peng J*. Rapid Detection of Antimicrobial Resistance in Mycoplasma genitalium by High-Resolution Melting Analysis with Unlabeled Probes. Microbiol Spectr. 2022, 10(4):e0101422

  17. Li Y#, Zhang L#, Xiu L#, Wang D, Zeng Y, Wang F, Yin Y, Peng J*. A Multiplex Molecular Assay for Detection of Six penA Codons To Predict Decreased Susceptibility to Cephalosporins in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2022, 66(3):e0170921

  18. Zhang C#, Song F#, Xiu L#, Liu Y, Yang J, Yao L, Peng J. Identification and characterization of a novel rodent bocavirus from different rodent species in China. Emerg Microbes Infect. 2018, 7(1):48 (Co-first author)

  19. Sun L#, Xiu L#, Zhang C#, Xiao Y, Li Y, Zhang L, Ren L*, Peng J*. Detection and classification of SARS-CoV-2 using high-resolution melting analysis. Microb Biotechnol, 2022, 15(6):1883-1894

  20. Zhang C#, Xiu L#, Xiao Y, Xie Z, Ren L, Peng J. Simultaneous Detection of Key Bacterial Pathogens Related to Pneumonia and Meningitis Using Multiplex PCR Coupled With Mass Spectrometry. Front Cell Infect Microbiol. 2018, 8:107

  21. Li Y, Xiu L, Liu J, Zhang C, Wang F, Yin Y, Peng J. A multiplex assay for characterization of antimicrobial resistance in Neisseria gonorrhoeae using multi-PCR coupled with mass spectrometry. J Antimicrob Chemother. 2020, 75(10):2817-25

  22. Binder RA, Alarja NA, Robie ER, Kochek KE, Xiu L, Rocha-Melogno L, Abdelgadir A, Goli SV, Farrell AS, Coleman KK, Turner AL, Lee MJ, Polage CR, Anderson BD, Gray GC. Environmental and Aerosolized SARS-CoV-2 Among Hospitalized COVID-19 Patients. J Infect Dis. 2020, 222(11):1798-1806

  23. Zhang C, Wang F, Zhu C, Xiu L, Li Y, Li L, Liu B, Li Y, Zeng Y, Guo B, Peng J. Determining antimicrobial resistance profiles and identifying novel mutations of Neisseria gonorrhoeae genomes obtained by multiplexed MinION sequencing. Sci China Life Sci. 2020, 63:1063-70

  24. Yuan Q, Li Y, Xiu L, Zhang C, Fu Y, Jiang C, Tang L, Peng J. Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017-2018. Emerg Microbes Infect. 2019, 8:1546-9

  25. Peng J, Yin Y, Chen S, Yang J, Dai X, Zheng H, Gu W, Zhu B, Yong G, Zhong N, Hu L, Cao W, Zheng Z, Wang F, Zhi Q, Zhang C, Xiu L, Liu B, Dong J, Sun L, Zhu Y, Chen X, Jin Q. A Whole-genome Sequencing Analysis of Neisseria gonorrhoeae Isolates in China: An Observational Study. EClinicalMedicine, 2019,7:47-54  

  26. Zhang C, Xiu L, Li Y, Sun L, Ren L, Li Y, Zeng Y, Wang F, Peng J. Multiplex PCR and Nanopore Sequencing of Genes Associated with Antimicrobial Resistance in Neisseria gonorrhoeae Directly from Clinical Samples. Clin Chem. 2021, 67(4):610-620

  27. Li H, Xie Y, Chen F, Bai H, Xiu L, Zhou X, Guo X, Hu Q, Yin K. Amplification-free CRISPR/Cas detection technology: challenges, strategies, and perspectives. Chem Soc Rev. 2023, 52(1):361-382

  28. Sun L, Zhang C, An S, Chen X, Li Y, Xiu L, Xu B, Xie Z, Peng J. Comprehensive Description of Pathogens and Antibiotic Treatment Guidance in Children with Community-acquired Pneumonia Using Combined Mass Spectrometry Methods. Front Cell Infect Microbiol. 2021, 11: 695134

  29. Vlasova AN, Diaz A, Damtie D, Xiu L, Toh TH, Lee JS, Saif LJ, Gray GC. Novel Canine Coronavirus Isolated from a Hospitalized Pneumonia Patient, East Malaysia. Clin Infect Disl. 2022, 74(3):446-454

  30. Wang X, Xiu L, Binder RA, Toh TH, Lee JS, Ting J, Than ST, Qi W, Coleman KK, Perera D, Ma M, Gray GC. A pan-coronavirus RT-PCR assay for rapid viral screening of animal, human, and environmental specimens. One Health. 2021, 13:100274

  31. Liu T, Xiu L, Yin K, Li S. Dominant mutations in the severe acute respiratory syndrome coronavirus-2 genome challenge polymerase chain reaction detection. Clin Transl Discov. 2022, 2(1):e23.

 

 

 

 

NameLeshan Xiu

DegreeMD

TitleAssistant Professor

Email Address: xiuls@sjtu.edu.cn

Office Address: Rm 412, Building 1, 280 South Chongqing Road, Shangha

Office Tel: 021-63846590


Education

2011.09 – 2015.06, North China University of Science and Technology, Bachelor

2015.09 – 2018.06, Peking Union Medical College, Tsinghua University, Master

2018.09 – 2021.06, Peking Union Medical College, Tsinghua University, MD

2019.09 – 2020.09, Duke University, Joint PhD student

 

Appointments

2021.07-present, Shanghai Jiao Tong University School of Medicine, Assistant Professor

 

Academic Participation and Activities

Youth Editorial Board Member of iMeta

Youth Editorial Board Member of Infectious Medicine

Youth Editorial Board Member of LabMed Discovery

Editor of Science in One Health

Guest Editor for Frontiers in Cellular and Infection Microbiology

 

Research Interest

Emergency prevention and control of emerging infectious diseases and pathogen discovery; Application of the One Health approach in infectious disease and antimicrobial resistance research;

Mechanisms of antimicrobial resistance and development of resistance elimination strategies; Development, application, and promotion of pathogen identification and resistance detection technologies.


 

 

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